Aging and 3,4-diaminopyridine alter synaptosomal calcium uptake.
نویسندگان
چکیده
منابع مشابه
Synaptosomal calcium uptake unaltered by adenosine and 2-chloroadenosine.
Purinergic compounds can decrease neural activity peripherally and centrally [l-4]. The spontaneous firing rates of cerebellar Purkinje neurons fall precipitously after adenosine or its analogs are applied locally [5]. The amplitude of hippocampal excitatory postsynaptic potential (EPSP) responses is depressed by adenosine and its analogs [S, 61. The depression of EPSP amplitudes of pyramidal n...
متن کامل[Ethanol and synaptosomal calcium binding].
27. C-L. Schengrund and J. T. Nelson, Biochem. biophys. Res. Commun. 63,217 (1975). 28. H. Rosner, M. Muhleisen, W. Probst and H. Rahmann, Hoppe-Seyler's Z. physiol. Chem. 360, 354 (1979). 29. D. T. Wang, J. S. Horng, F. P. Bymaster, K. L. Hauser and B. B. Molloy, Life Sci. 15,471 (1974). 30. L. Lemberger, H. Rowe, R. Carmichael, R. Crabtree, J. S. Horng, F. Bymaster and D. Wang, Clin. Pharmac....
متن کاملAntioxidant activity of X-34 in synaptosomal and neuronal systems.
Inhibiting aggregation and deposition of amyloid beta-peptide (Abeta) in brain is a therapeutic strategy for Alzheimer's disease (AD). A Congo-red-like molecule, X-34, is reported to bind to Abeta deposits. Oxidative stress associated with Abeta is hypothesized to be critical for the neurotoxic properties of this peptide. The present study was undertaken to test the hypothesis that X-34, with i...
متن کاملEffect of paraoxon on the synaptosomal GABA uptake in rat hippocampus and cerebral cortex
Introduction: Paraoxon (the neurotoxic metabolite of organophosphorus (OP) insecticide, parathion) exerts acute toxicity by inhibition of acetylcholinesterase (AChE), leading to the accumulation of acetylcholine in cholinergic synapses and hence overstimulation of the cholinergic system. Since, reports on changes in the level of γ- amino butyric acid (GABA) during OP-induced convulsion have bee...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1983
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(17)44252-9